The October international schedule came to an end on Tuesday with five Saints representing their countries.
Maya Yoshida earned his 99th cap for Japan in their 3-0 win against Tajikistan.
Captaining the side to a 6-0 victory over Mongolia last week, the defender had the armband once again as a Takumi Minamino brace and Takuma Asano header secured all three points.
The win sees the Samurai Blue continue their 100% start to World Cup qualification, sitting top of Group F.
Whilst Yoshida approaches his century, two Saints youngsters were on display for Republic of Ireland Under-21s in their Under-21 Euro 2021 qualifier.
Travelling to Reykjavik to take on their Icelandic counterparts, Michael Obafemi was awarded a first start whilst Southampton Under-23s defender Kameron Ledwidge was handed a debut.
Drawing 0-0 with Italy on Thursday, Stephen Kenny’s side suffered a disappointing 1-0 defeat, with Obafemi substituted on 75 minutes.
Also falling to defeat in their group were Austria Under-21s, captained by Kevin Danso.
Any hopes of a fairytale return to MK Dons - where the defender was part of the academy - were extinguished by an Eddie Nketiah hat-trick and Callum Hudson-Odoi double, with Christoph Baumgartner netting a consolation in a 5-1 defeat.
Rounding off the October international break, Pierre-Emile Højbjerg completed the whole match for Denmark in their 4-0 friendly win against Luxembourg.
A brace from Kasper Dolberg and further strikes from Martin Braithwaite and Christian Gytkær made it two wins from two for Højbjerg and his compatriots.